【論文】
Resveratrol is converted to the ring portion of coenzyme Q10 and raises intracellular coenzyme Q10 levels in HepG2 cell
Rena Okuizumi, Riku Harata, Mizuho Okamoto, Seiji Sato, Kyosuke Sugawara, Yukina Aida, Akari Nakamura, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba
Journal of Clinical Biochemistry and Nutrition 2024
Hori A, Inaba H, Hato T, Tanaka K, Sato S, Okamoto M, Horiuchi Y, Paran FJ, Tabe Y, Mori S, Rosales C, Akamatsu W, Murayama T, Kurebayashi N, Sakurai T, Ai T, Miida T.PLoS One. 2024 Aug 22;19(8):e0291887.
AI-based Apoptosis Cell Classification Using Phase-contrast Images of K562 Cells.
Kikuchi Y, Okuhashi Y, Ishihata H, Kashiba M, Sasaki S.Anticancer Res. 2024 Mar;44(3):935-939.
Transferrin, insulin, and progesterone modulate intracellular concentrations of coenzyme Q and cholesterol, products of the mevalonate pathway, in undifferentiated PC12 cells.
Nakamura A, Aida Y, Okamoto M, Maeda A, Nagao A, Kitatani K, Takekoshi S, Fujisawa A, Yamamoto Y, Kashiba M. J Clin Biochem Nutr. 2023 May;72(3):199-206.
Method for detecting CoQ10 incorporation in the mitochondrial respiratory chain supercomplex.
Sugawara K, Sato S, Tanaka Y, Nakamura A, Fujisawa A, Yamamoto Y, Kashiba M.J Clin Biochem Nutr. 2023 May;72(3):207-214.
Riboflavin compounds show NAD(P)H dependent quinone oxidoreductase-like quinone reducing activity.
Nagase M, Sakamoto M, Amekura S, Akiba S, Kashiba M, Yokoyama K, Yamamoto Y, Fujisawa A.J Clin Biochem Nutr. 2023 Jul;73(1):52-60.
Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency.
Hikaru Takeuchi, Kyosuke Sugawara, Mizuho Okamoto, Akari Nakamura, Tsukika Tanaka, Yui Fujita, Kaiho Ishiguro, Hana Yamazaki, Maiko Okada, Akane Mikami, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba.
J Clin Biochem Nutr. 2022 Sep;71(2):97-102.
Cellular level of coenzyme Q increases with neuronal differentiation, playing an important role in neural elongations.
Akari Nakamura, Mizuho Okamoto, Ayaka Maeda, Huiyu Jiang, Kyosuke Sugawara, Kanae Kitatani, Susumu Takekoshi, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba.
J. Clin. Biochem. Nutr. 2022 Sep;71(2):89-96.
Coenzyme Q10 levels increase with embryonic development in medaka.
Mizuho Okamoto, Akari Nakamura, Ayaka Maeda, Yuka Kameda, Kyosuke Sugawara, Marisa Takekawa, Momoko Ogino, Eriko Makino, Nagisa Ishii, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba.
J. Clin. Biochem. Nutr. Vol. 70 (2022), No. 3 pp. 231-239
Differentiation of THP-1 monocytes to macrophages increased mitochondrial DNA copy number but did not increase expression of mitochondrial respiratory proteins or mitochondrial transcription factor A.
Mizuho Okamoto, Masanori Shimogishi, Akari Nakamura, Yusuke Suga, Kyosuke Sugawara, Michio Sato, Ryotaro Nishi, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba.
Arch Biochem Biophys. 2021 Oct 15;710:108988.
Prosaposin knockdown in Caco-2 cells decreases cellular levels of coenzyme Q10 and ATP, and results in the loss of tight junction barriers.
Kashiba M, Terashima M, Sagawa T, Yoshimura S, Yamamoto Y.
J Clin Biochem Nutr. 2017 Mar;60(2):81-85. doi: 10.3164/jcbn.16-32. Epub 2016 Dec 6.
Prosaposin regulates coenzyme Q10 levels in HepG2 cells, especially those in mitochondria.
Kashiba M, Oizumi M, Suzuki M, Sawamura Y, Nagashima K, Yoshimura S, Yamamoto Y.
J Clin Biochem Nutr. 2014 Sep;55(2):85-9. doi: 10.3164/jcbn.13-106. Epub 2014 Jul 4.
Dynamic aspects of ascorbic acid metabolism in the circulation: analysis by ascorbate oxidase with a prolonged in vivo half-life.
Kasahara E, Kashiba M, Jikumaru M, Kuratsune D, Orita K, Yamate Y, Hara K, Sekiyama A, Sato EF, Inoue M.
Biochem J. 2009 Jun 26;421(2):293-9. doi: 10.1042/BJ20090286.
Repeated edaravone treatment reduces oxidative cell damage in rat brain induced by middle cerebral artery occlusion.
Yamamoto Y, Yanagisawa M, Tak NW, Watanabe K, Takahashi C, Fujisawa A, Kashiba M, Tanaka M.
Redox Rep. 2009;14(6):251-8. doi: 10.1179/135100009X12525712409779.
Effects of various concentrations of inhaled oxygen on tissue dysoxia, oxidative stress, and survival in a rat hemorrhagic shock model.
Takasu A, Iwamoto S, Ando S, Minagawa Y, Kashiba M, Yamamoto Y, Sakamoto T.
Resuscitation. 2009 Jul;80(7):826-31. doi: 10.1016/j.resuscitation.2009.03.018. Epub 2009 May 1.
Coenzyme Q10-Binding/Transfer Protein Saposin B also Binds gamma-Tocopherol.
Jin G, Horinouchi R, Sagawa T, Orimo N, Kubo H, Yoshimura S, Fujisawa A, Kashiba M, Yamamoto Y.
J Clin Biochem Nutr. 2008 Sep;43(2):95-100. doi: 10.3164/jcbn.2008052.
Saposin B is a human coenzyme q10-binding/transfer protein.
Jin G, Kubo H, Kashiba M, Horinouchi R, Hasegawa M, Suzuki M, Sagawa T, Oizumi M, Fujisawa A, Tsukamoto H, Yoshimura S, Yamamoto Y.
J Clin Biochem Nutr. 2008 Mar;42(2):167-74. doi: 10.3164/jcbn.2008024.
Erythrocytes with T-state-stabilized hemoglobin as a therapeutic tool for postischemic liver dysfunction.
Suganuma K, Tsukada K, Kashiba M, Tsuneshige A, Furukawa T, Kubota T, Goda N, Kitajima M, Yonetani T, Suematsu M.
Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1847-55.
Cadmium exposure alters metabolomics of sulfur-containing amino acids in rat testes.
Sugiura Y, Kashiba M, Maruyama K, Hoshikawa K, Sasaki R, Saito K, Kimura H, Goda N, Suematsu M.
Antioxid Redox Signal. 2005 May-Jun;7(5-6):781-7.
Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver.
Fujii K, Sakuragawa T, Kashiba M, Sugiura Y, Kondo M, Maruyama K, Goda N, Nimura Y, Suematsu M.
Antioxid Redox Signal. 2005 May-Jun;7(5-6):788-94.
Vitamin E prevents increase in oxidative damage to lipids and DNA in liver of ODS rats given total body X-ray irradiation.
Yoshimura M, Kashiba M, Oka J, Sugisawa A, Umegaki K.
Free Radic Res. 2002 Jan;36(1):107-12.
Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity.
Hori R, Kashiba M, Toma T, Yachie A, Goda N, Makino N, Soejima A, Nagasawa T, Nakabayashi K, Suematsu M.
J Biol Chem. 2002 Mar 22;277(12):10712-8. Epub 2002 Jan 10.
Impaired ascorbic acid metabolism in streptozotocin-induced diabetic rats.
Kashiba M, Oka J, Ichikawa R, Kasahara E, Inayama T, Kageyama A, Kageyama H, Osaka T, Umegaki K, Matsumoto A, Ishikawa T, Nishikimi M, Inoue M, Inoue S.
Free Radic Biol Med. 2002 Nov 1;33(9):1221-30.
From O2 to H2S: a landscape view of gas biology.
Kashiba M, Kajimura M, Goda N, Suematsu M.
Keio J Med. 2002 Mar;51(1):1-10. Review.
Moderate physical exercise induces the oxidation of human blood protein thiols.
Inayama T, Oka J, Kashiba M, Saito M, Higuchi M, Umegaki K, Yamamoto Y, Matsuda M.
Life Sci. 2002 Mar 15;70(17):2039-46.
Different origin of hypertriglyceridemia induced by a high-fat and a high-sucrose diet in ventromedial hypothalamic-lesioned obese and normal rats.
Xue CY, Kageyama H, Kashiba M, Kobayashi A, Osaka T, Namba Y, Kimura S, Inoue S.
Int J Obes Relat Metab Disord. 2001 Mar;25(3):434-8.
Metabolic cooperation of ascorbic acid and glutathione in normal and vitamin C-deficient ODS rats.
Wang Y, Kashiba M, Kasahara E, Tsuchiya M, Sato EF, Utsumi K, Inoue M.
Physiol Chem Phys Med NMR. 2001;33(1):29-39.
Oxidative cellular damage associated with transformation of Helicobacter pylori from a bacillary to a coccoid form.
Nakamura A, Park A, Nagata K, Sato EF, Kashiba M, Tamura T, Inoue M.
Free Radic Biol Med. 2000 Jun 1;28(11):1611-8.
Impaired reductive regeneration of ascorbic acid in the Goto-Kakizaki diabetic rat.
Kashiba M, Oka J, Ichikawa R, Kageyama A, Inayama T, Kageyama H, Ishikawa T, Nishikimi M, Inoue M, Inoue S.
Biochem J. 2000 Oct 15;351 Pt 2:313-8.
Nitric oxide-independent effects of nitric oxide donors on energy metabolism in erythrocytes.
Kashiba M, Inoue M.
Biochem Pharmacol. 2000 Mar 1;59(5):557-61.
Role of glutathione in stabilization of nitric oxide during hypertension developed by inhibition of nitric oxide synthase in the rat.
Pechánová O, Kashiba M, Inoue M.
Jpn J Pharmacol. 1999 Oct;81(2):223-9.
Rapid increase in circulating leptin in ventromedial hypothalamus-lesioned rats: role of hyperinsulinemia and implication for upregulation mechanism.
Suga A, Hirano T, Kageyama H, Kashiba M, Oka J, Osaka T, Namba Y, Tsuji M, Miura M, Adachi M, Inoue S.
Diabetes. 1999 Oct;48(10):2034-8.
Cross-talk of NO, superoxide and molecular oxygen, a majesty of aerobic life.
Inoue M, Nishikawa M, Sato EF, Ah-Mee P, Kashiba M, Takehara Y, Utsumi K.
Free Radic Res. 1999 Oct;31(4):251-60. Review.
Fates and vascular action of S-nitrosoglutathione and related compounds in the circulation.
Kashiba M, Kasahara E, Chien KC, Inoue M.
Arch Biochem Biophys. 1999 Mar 15;363(2):213-8.
[Chemistry and biology of peroxynitrite].
Konaka R, Kashiba M, Inoue M.
Seikagaku. 1998 Feb;70(2):84-95. Review. Japanese. No abstract available.
Helicobacter pylori generates superoxide radicals and modulates nitric oxide metabolism.
Nagata K, Yu H, Nishikawa M, Kashiba M, Nakamura A, Sato EF, Tamura T, Inoue M.
J Biol Chem. 1998 Jun 5;273(23):14071-3.
Role of glutathione in nitric oxide-dependent regulation of energy metabolism in rat hepatoma cells.
Nishikawa M, Sato EF, Kashiba M, Kuroki T, Utsumi K, Inoue M.
Hepatology. 1998 Feb;27(2):422-6.
Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats.
Kageyama H, Suga A, Kashiba M, Oka J, Osaka T, Kashiwa T, Hirano T, Nemoto K, Namba Y, Ricquier D, Giacobino JP, Inoue S.
FEBS Lett. 1998 Dec 4;440(3):450-3.
Oxygen-dependent regulation of the respiration and growth of Escherichia coli by nitric oxide.
Yu H, Sato EF, Nagata K, Nishikawa M, Kashiba M, Arakawa T, Kobayashi K, Tamura T, Inoue M.
FEBS Lett. 1997 Jun 9;409(2):161-5.
Effect of nitric oxide on the ligand-binding activity of albumin.
Kashiba-Iwatsuki M, Miyamoto M, Inoue M.
Arch Biochem Biophys. 1997 Sep 15;345(2):237-42.
Role of ascorbic acid in the metabolism of S-nitroso-glutathione.
Kashiba-Iwatsuki M, Yamaguchi M, Inoue M.
FEBS Lett. 1996 Jul 1;389(2):149-52.
Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols.
Kashiba-Iwatsuki M, Kitoh K, Kasahara E, Yu H, Nisikawa M, Matsuo M, Inoue M.
J Biochem. 1997 Dec;122(6):1208-14.
Action of beta-carotene as an antioxidant against lipid peroxidation.
Tsuchihashi H, Kigoshi M, Iwatsuki M, Niki E.
Arch Biochem Biophys. 1995 Oct 20;323(1):137-47.
Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.
Iwatsuki M, Niki E, Stone D, Darley-Usmar VM.
FEBS Lett. 1995 Mar 6;360(3):271-6.
Effects of solvents and media on the antioxidant activity of alpha-tocopherol
Iwatsuki M, Tsuchiya J, Komuro E, Yamamoto Y, Niki E.
Biochim Biophys Acta. 1994 May 25;1200(1):19-26.
Antioxidant activities of natural and synthetic carbazoles.
Iwatsuki M, Niki E, Kato S.
Biofactors. 1993 May;4(2):123-8.
